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Beyond mitochondria, several intracellular enzymes contribute to the production of reactive oxygen species (ROS) and reactive nitrogen species (RNS): NADPH oxidases, xanthine oxidoreductase, certain peroxisomal oxidases, cytochrome P450 enzymes, cyclooxygenases, and lipoxygenases

Apparently trauma also can be a trigger

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Liver Health Support: May reduce liver fat and support patients with nonalcoholic fatty liver disease (NAFLD)