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Description
This metabolic perturbation significantly downregulates the expression of intestinal tight junction proteins, particularly ZO-1 (Mishra et al., 2023), thereby initiating a multistep pathogenic cascade: (i) compromised intestinal barrier integrity promotes bacterial translocation and systemic dissemination of deleterious metabolites

2b), consistent with the association between the stability of these proteins and the fidelity of Fe-S cluster synthesis 41

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Glutathione helps reduce oxidative stress, one of the key drivers of cellular aging
