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Solid lipid nanoparticles: production, characterization and applications

Among the various compounds synthesized, the alkyl-based PROTAC 73 stands out, capable of inducing in vitro a selective and potent proteasome-dependent degradation of the target protein (DC 50 value of 214 nM), resulting in a favorable antiproliferative effect (IC 50 value of 1.3 M) 128

210 mg/kg twice daily p.o.) was administered every day on days -2 to 12

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