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Description
Blockage of Bcl-XL function by PUMA- gives way to Bax and Bak to change their conformation and form pores in the outer mitochondrial membrane, leading to the cytochrome c release into cytosol, apoptosome formation, subsequent caspase activation, and following apoptosis [33, 34]
doi: 10.2119/molmed.2011.00080
NAC is not absorbed well in the body due to its low bioavailability as an oral supplement
Furthermore, it is recommended that investigators assess any systematic differences in outcomes and/or exposures between participants who completed the study and those who were lost to follow-up
