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Novel neuromodulation technologies are evolving beyond traditional openloop systems, with closedloop SCS systems representing a significant advance
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There is growing consensus regarding their pathophysiology and management, but more work is needed to elucidate the relationships between irAEs and treatment outcomes, specific biomarkers that clinch an irAE diagnosis, the impact of tailored immunosuppression on ICI outcomes, and the management of steroid-refractory irAEs
Can IV glutathione therapy be combined with other treatments to boost detoxification
