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Most of the brain targeting agents were derived from a receptor- or carrier-mediated transcytosis process at the BBB

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Therefore, using FDA approved nanotechnology, chemical adjuvant and bio-degradable and low toxic peptide conjugation, such as liposomes, maleimide, which frequently regarded as ADC linker and peptide, respectively, to rescue candidate drugs, offering a new strategy for drug development with potential in clinical use

Peptides are short polymers typically composed of fewer than 50 amino acids and generally have a molecular weight of less than 10 kDa