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Description
astrocytes type 2 ( Apoe , Clu , and Cst3 )
For clinicians : Intervening at the systems level targeting oxidative stress, toxin burden, microbiome imbalance, and metabolic dysregulation can meaningfully slow disease progression
Depending on stimuli, microglia can adopt distinct phenotypes: the M1 pro-inflammatory state (induced by lipopolysaccharide and characterized by production of cytokines such as TNF-, IL-1, and IL-6) and the M2 anti-inflammatory state (induced by IL-4 or IL-13, promoting repair) [122, 123]
doi: 10.1038/lsa.2015.137
