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[DOI] [PMC free article] [PubMed] [Google Scholar] 144.Barysheva M, Jahanshad N, Foland-Ross L, Altshuler LL, Thompson PM

3.4 Improved cellular uptake Upon exposure to mildly acidic conditions of the tumour microenvironment (around pH 6.56.8), ionizable groups such as amines, imidazoles, or carboxyl-based moieties, CRNs become protonated or lose their protective shells, leading to a shift in surface charge from negative to positive

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