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Elevated ROS cause apoptosis by increasing the permeability of the outer mitochondrial membrane leading to the release of pro-apoptotic factors, such as cytochrome c, caspase, etc
L.CavodeassiF.SchwarzQ.et al
[112] showed that the use of IN NPs delivery system enables the administration of a selective opioid receptor (DOR) agonist, leucine-kephalin hydrochloride (LENK), to the brain
2023b;329:15671578
