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Description
Studies indicate that NNMT inhibition by compounds such as 5-Amino-1MQ can result in reduced fat mass and improved insulin resistance
Current research priorities include large-scale studies to better understand the tissue-specific effects of NNMT inhibition and the temporal dynamics of metabolic reprogramming following treatment
Metabolic Rewiring: By stopping the conversion of nicotinamide (NAM) into 1-methylnicotinamide (1-MNA), the cell is forced to recycle NAM into NAD+
AOD-9604 has been evaluated for selective interaction with lipid metabolism pathways
