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285,286,287 The MAPK pathway is an important pathway related to UC, 288 and its inhibition reduces inflammation by downregulating the levels of proinflammatory cytokines

Some protocols begin with a brief intensive phase (for example, daily or alternate-day dosing) followed by a maintenance phase (for example, weekly to monthly), particularly for B12 deficiency

Key considerations for clinical use include its unapproved status and the unregulated supplement market

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