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Continued research into the immunological aspects of ammonia metabolism in the TME is essential for advancing tumor immunotherapy targeting ammonia death, with the goal of achieving innovative breakthroughs in cancer treatment and providing clinical benefits to cancer individuals

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The model described in the present article is available via Github ( and Google Colab ( It is also available for use at the Open Brain Platform hosted by the Open Brain Institute ( under the following DOI: 10.25453/fsci.28653347

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