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For in silico libraries without detectability filtering, Trypsin and Trypsin/P were set as the digestion enzyme with no missed cleavages, respectively, and the results were combined

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doi: 10.1016/j.regpep.2012.12.007

The combination of these R 8 GD modified liposomes demonstrated potent toxicity against highly invasive breast cancer (MDA-MB-435S) cells, effectively suppressing the formation of vasculogenic mimicry (VM) channels, and inhibiting tumor cell metastasis by down-regulating HIF-1 , MMP-2, TGF- 1 and VE-cad [442]