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Notably, a combination of low BEC and high FeNO significantly reduced modified Reiff scores and exacerbation rates, suggesting that BEC and FeNO reflect distinct aspects of disease severity, as seen in a retrospective Chinese cohort [38], akin to findings in a prior COPD study [30]

doi: 10.4155/fmc-2018-0436

In addition, severe vitamin B 12 deficiency in patients with AIG may result in neurological damage, causing symptoms such as impaired peripheral nerve function and sensory, abnormal proprioception, ataxia, paresthesia, numbness, mood disorders, cognitive impairment and psychosis