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Description
Systemic side effects may occur in some individuals

Randomization: AOD-9604 at doses 0.25, 0.5, 1.0 mg daily SC vs placebo
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These provide additional tyrosine residues to be phosphorylated by the tyrosine kinase domain of the activated receptor that will attract further molecules containing SH2 domains or plekstrin homoly (PH) domains, these last will anchor IRS to phosphoinositides on the cell membrane