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The 2018 guideline recommends screening for risk factors and symptoms of depression and anxiety at time of diagnosis
Other studies have also shown that chronic administration of rotenone over a long period can increase nitric oxide and lipid peroxidation products in the brain cortex and striatum in rats, which then clearly mimic parkinsonian behavioral symptoms such as akinesia and rigidity
10.1016/j.chemphyslip.2013.01.002
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