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In the glycolytic pathway, hexokinase II (HX-2) and glyceraldehyde phosphate dehydrogenase (GAPDH) in particular have been identified as targets [28,29,30]

this induces the production of O 2 (among other ROS) and its subsequent dismutation to H 2 O 2 [41]

Following the addition of ATP, the initial rate of NADH consumption was monitored by measuring the absorbance every minute at 340 nM for 3045 min on a Synergy Neo2 Multi-mode Microplate Reader (BioTek)

Subchronic As administration to rats (NaAsO 2 at 3 and 10 mg/Kg/day/412 weeks, intragastric) induced P-Tau, suggesting that As-destabilization and disruption of the cytoskeletal framework may lead to axonal degeneration (Vahidnia et al., 2008)