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avoiding high-fat foods Temporary dose reduction Stepping back to previous dose if symptoms severe Antiemetic support When appropriate under medical supervision Contraindications and Precautions Certain populations should exercise particular caution with cagrilintide: Personal or family history of medullary thyroid carcinoma Multiple Endocrine Neoplasia syndrome type 2 (MEN 2) Severe gastrointestinal disease History of pancreatitis Pregnancy or breastfeeding These contraindications overlap significantly with those for GLP-1 receptor agonists like tirzepatide, making combination approaches even more critical to approach cautiously

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2020;53:e12808

Pelvic floor muscle dysfunction may manifest as high resting urethral pressure, functional bladder outlet obstruction due to poor relaxation of the sphincter associated with pain-induced pelvic floor muscle dysfunction, and poor contractility due to bladder inhibition from non-relaxing pelvic floor muscles