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These synaptological rearrangements in POMC neurons are in tight parallel with the effects of estrogens on food intake, energy expenditure, and body weight (34)

They were referring to a study by the Federal Drug Authority in USA who looked at the effectiveness of old drugs,, some as old as thirty years and found them still as good as new.The NHS take a different view

Symptoms include fatigue, reduced libido, depression, decreased muscle mass , and cognitive fog