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This bacterium drives ferroptosis in periodontal cells by modulating iron metabolism, lipid metabolism, and the antioxidant system, thereby forming a self-amplifying inflammatory circuit that exacerbates disease progression

Highly reactive species such as hydroxyl radical (OH) and perhydroxyl radical (HO 2 ) emerge from secondary interactions involving O 2 - NAFLD progression is further driven by insulin resistance (IR), ER stress, and the activation of the unfolded protein response (UPR) pathway [52, 53]

Looking ahead : The continued study of Epitalon may unlock novel, personalized anti-aging therapies and help shape the future of regenerative medicine

In response to concerns about residual solvents, cold-press extraction has emerged as an alternative method to reduce solvent residues and minimize protein denaturation, as demonstrated in studies on Hermetia illucens larvae (Kim et al., 2022)