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We posit that antioxidant functions of parkin may explain many of its previously described, protective effects in vertebrates and invertebrates that are unrelated to E3 ligase activity

Soluble adhesion molecule levels in diabetic patients are significantly higher than those in healthy controls, and excessive expression of adhesion molecules may induce an inflammatory response and tissue injury

Based on their amino acid sequence, plant PPOs can be divided into two phylogenetic groups (group 1 and group 2), and it has been shown recently that members of group 1 exhibit mono- and diphenolase activity, whereas group 2 PPOs are only active on diphenols 32,33

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