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What has been lacking is an integrated and quantitative understanding of the kinetics of APAP metabolism, of how APAP dosage affects NAPQI synthesis and GSH concentrations in the liver, of how NAC stimulates the synthesis of GSH, and of how the dosage and timing of NAC affect detoxification of NAPQI

[DOI] [PMC free article] [PubMed] [Google Scholar] 70.Frye RE, Sequeira JM, Quadros EV, James SJ, Rossignol DA

4a), NPs (20 mg/kg, 200 l) were intravenously injected into mice after 14, 17, and 20 days of cell inoculation, respectively

Assessing genomic diversity and signatures of selection in Jiaxian Red cattle using whole-genome sequencing data