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In rodent studies, animals with greater GLUT4 expression display heightened insulin sensitivity, whereas those with reduced GLUT4 levels demonstrate impaired insulin signaling
SMAD4 loss in the hindgut is associated with worse recurrence-free survival
Collectively, these OFF-to-ON switching strategies illustrate therapeutic approaches in which GSH acts as a biological trigger for selective activation of cytotoxic agents in the GSH-rich tumor microenvironment
