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The Intestinal Epithelial Barrier Mucus The mucus layer covers the luminal surface of the GI tract and is the first line of defense against mechanical, chemical, and biological insults

Reville PK, MD, MPH, Kantarjian H, MD, Borthakur G, MD, Pemmaraju N, MD, DiNardo CD, MD, MSCE, Sasaki K, MD, PhD, Daver N, MD, Issa GC, MD, Ohanian M, DO, Montalban-Bravo G, MD, Short NJ, MD, Jain N, MD, Bhalla KN, MD, Jabbour EJ, MD, Ferrajoli A, MD, Takahashi K, MD, PhD, Rausch CR, PharmD, Malla R, RN, BSN, Marek K, Brandt M, BS, Popat UR, MD, Andreeff M , MD, PhD, Garcia-Manero G, MD, Konopleva M, MD, PhD, Ravandi F, MBBS, Kadia TM, MD

Powerful Antioxidant ProtectionReduced glutathione is one of the most powerful antioxidants in the human body

In this way, DBH inhibition would decrease excitatory drive onto midbrain dopamine neurons, and thus, despite increased tissue levels of dopamine, the firing of dopaminergic neurons (particularly burst firing) would be attenuated, and extracellular DA levels would actually fall