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These cases can seem particularly challenging, as performing surgery, radioactive iodine treatment or starting life-long medication can feel overzealous

However, it is important to recognise that whilst they are widely available, the regulatory framework for food supplements differs significantly from that of licensed medicines, and claims made about their efficacy should be evaluated critically against available evidence

This interplay between mtDNA and nDNA is crucial because disruptions in this interaction can exacerbate mitochondrial dysfunction and further impair energy production in cells [12]

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