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Both are well studied, unanimously accepted among researchers, and present in all ME/CFS patients (at least if diagnosed according to the now internationally accepted Canadian Consensus Criteria) (Carruthers et al., 2003)

Brain purinergic activity linked with depressive symptomatology: hypoxanthine and xanthine in CSF of patients with major depressive disorders

3.6.3.3 Immune modulation Long-term use of proton pump inhibitors (PPI), while effective for acid-related disorders, has been shown to alter gut microbiota composition and increase the risk of infections such as SIBO and C

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