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Pyroptosis and Insulin Resistance in Metabolic Organs

It seems that antioxidants that inhibit lipid peroxidation and/or lipoxygenase activity (such as NDGA, BHA, Vitamin E, or Mitovitamin E), but not antioxidants that scavenge water-soluble ROS (such as catalase, superoxide dismutase, or ascorbate) can interfere with the activation of primary T cells (Fig

It is better understood as a stress-responsive metabolic signal that can move to the nucleus and influence gene-expression programs tied to energy balance

however, these interventions have either triggered hemolysis (ascorbate) or have not prevented AHA in the face of a stressor (-tocopherol, ALA), despite improvements in hematological parameters
