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10.1136/bmj.g2272 13

For example, when wild-type p53 was induced in colon cancer cells expressing a mutant p53 protein, sensitivity to 5-FU, camptothecin, and radiation was increased (Yang et al, 1996)

The main proteins responsible are sulfhydryl oxidases, which often incorporate iron, copper, or flavin binding domains to participate in oxidation-reduction reactions (Kodali and Thorpe, 2010)

Additionally, it protects the energy producing enzyme Glyceraldehyde 3-phosphate dehydrogenase from attack by nitric oxide.
