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It's the only antioxidant that can function in all cellular environments

The beneficial and restorative effects of stem cells are mainly due to their paracrine activity, in which stem cells generate and release extracellular vesicles such as exosomes and distinct secreted non-vesicle soluble proteins, including, growth factors, chemokines, cytokines, and immunomodulatory molecules referred to as the Secretome

Moreover, the overexpression of PHGDH in a mouse model resulted in resistance to erlotinib in xenografts, and the knockdown of PHGDH rescued the tumoricidal effect and restored sensitivity to erlotinib in both cell lines and xenografts (Dong et al., 2018)