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It is believed that REM sleep dysregulation symptoms arise from the sporadic activation of REM sleep-promoting neurons during wakefulness, which causes REM sleep manifestationslike cataplexyto intrude into wakefulness (Thorpy & Bogan, 2020)

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[] The shortage might be unchanging, resulting in lower iron storage, or functional, resulting in inadequate iron usage [Table 1]

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This suggests morphine analgesia is improved rather than impaired by engagement of arrestin-3 at MOR

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