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In clinical advancement, strategies with more realistic value include local delivery or use as adjuvant therapy, rather than relying on long-term systemic exposure
Liposomal encapsulation offers a solution here: the phospholipids protect the GSH molecule from enzymatic degradation in the gastrointestinal tract, after which absorption takes place partly via endocytosis and lymphatic transport
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Persistently activated Stat3 maintains constitutive NF-kappaB activity in tumors
