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In addition, treatment with L-buthionine-sulfoximine (BSO) to deplete glutathione decreased the ESCC tumor burden in mice, thus demonstrating the critical role of glutathione metabolism in ESCC progression

doi: 10.1016/j.dsx.2015.08.016

Proline accumulation, a compatible solute Numerous studies have shown the accumulation of proline, a key compatible solute, plays a central role in stress tolerance [3], while antioxidant enzymes such as superoxide dismutase (SOD), peroxidase (POD), catalase (CAT), and glutathione S-transferase (GST), together with antioxidants such as flavonoids and phenolics mitigate oxidative damage by neutralizing reactive oxygen species [6]

This combination supports enhanced recovery, sleep quality, and metabolic benefits while maintaining a well-tolerated profile