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With a candidate nozzle protein identified, we next attempted to visualize PilQ at the sites of slime secretion in situ

Injection of A42 into rat basal forebrain followed a week later by examination of oxidative damage in hippocampus demonstrated a significant elevated level of HNE-modified proteins (13), consistent with the known diffusion of HNE from its site of origin in cell or organelle membranes to other areas within the cell (8, 34) and consistent with the connection between the forebrain and outer molecular layer of hippocampus (98)

Statistical significance was determined at a P -value 0.05)

Increased ferric iron content and iron-induced oxidative stress in the brains of scrapie-infected mice