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Transition metal ions stimulate lipid peroxidation both through the Fenton reaction and by breaking down lipid hydroperoxides into more reactive peroxyl and alkoxyl radicals

This increase in volume allows bulkier ligands to enter the pocket, and this may induce AR promiscuity for other hormones and analogs, such as estrogens and progesterone

In clinical trials, tirzepatide produced dose-dependent weight loss, with higher doses (10 mg and 15 mg weekly) achieving greater reductions than lower doses

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