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The most common side effects of pemetrexed for injection when given alone are: tiredness nausea loss of appetite The most common side effects of pemetrexed for injection when given with cisplatin are: vomiting low white blood cell counts (neutropenia) swelling or sores in your mouth or sore throat low platelet counts (thrombocytopenia) constipation low red blood cell counts (anemia) The most common side effects of pemetrexed for injection when given with pembrolizumab and platinum chemotherapy are: tiredness/weakness nausea constipation diarrhea loss of appetite rash vomiting cough shortness of breath fever Pemetrexed for injection may cause fertility problems in males

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