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Oxid Med Cell Longev 2022:3846217 Hou Y, Cai S, Yu S, Lin H (2021) Metformin induces ferroptosis by targeting miR-324-3p/GPX4 axis in breast cancer

Would surmise this has something to do with blood-flow/circulation then

GPX2 and GPX3 exert antioxidant effects in intestinal epithelial cells and plasma, respectively [65]

's_Orthopaedic_Surgery_Chapter_273 Accessed June 26, 2019
