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At an IC50 of 24 mol/L, curcumin did not exhibit significant cytotoxicity but reduced ERK1/2 activity, resulting in cell cycle arrest and enhanced apoptosis (Wang et al., 2021)
Concerning the molecular mechanisms implicated in HGF angiogenic role, there is a strong association with the E-twenty-six (Ets) pathway, which is implicated in the regulation of developmental and mitogen signals (Aoki et al., 2000)
By enhancing this process, MOTS-C helps prevent the accumulation of metabolic byproducts that can lead to cellular dysfunction over time
doi: 10.1161/01.CIR.92.4.767
