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Mean smoking pack years was 40.32 35.18

It is volume loss, and that is why concealer can only do so much

The ZWF1 null mutant is a methionine auxotroph (Thomas et al., 1991), and shows decreased tolerance to oxidants, even in the presence of methionine, indicating that NADPH balance in the presence of methionine is critical (Campbell et al., 2016)

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