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It is present in virtually every cell, with the highest concentrations in the liver, immune cells, and the lens of the eye

However, more research is needed to definitively say whether this timing strategy offers significant benefits

Assessing GPx activity in tissue homogenates (e.g., lung, pancreas) or cell lysates (e.g., airway epithelial cells) is vital for understanding its contribution to CF pathology in affected organs

To ensure surfactant renewal, the lung utilizes circulating fatty acids from the bloodstream, which undergo intracellular remodeling before being incorporated into surfactant synthesis and secretion (Harayama et al., 2014)