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10,278 Genetic suppression of the IKK/NF-B pathway, achieved through the deletion of one p65 allele, or pharmacological intervention via IKK inhibitors, such as 8K-NBD, has been shown to delay the onset and mitigate the severity of aging symptoms and age-related pathologies in the nervous system of murine models 10,279

In the CCI model, cuminaldehyde not only alleviated allodynia and hyperalgesia at doses ranging from 25 to 100 mg/kg, but it also significantly decreased serum levels of the inflammatory cytokines TNF- and IL-1 (Koohsari et al., 2020)

Lyophilized metabolite extract was dissolved in 500 L deionized water and analyzed by LC-MS

Its moderate effects on growth hormone levels makes it good for studies that require sustained but controlled hormonal stimulation