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Serum B12, and potentially methylmalonic acid (MMA) and homocysteine, give your clinician the data to determine whether B12 is a contributing factor or whether the mood symptoms are being driven by something else entirely

Biol Direct

[29] For example, a 2012 study published in Nutrients found that people with B12 deficiency can have elevated levels of inflammatory markers like TNF- and resistin

As done in prior studies of body temperature and depression 19,21 , we computed metrics for the daily average distal body temperature during minutes awake (awake distal body temperature), the daily average during sleeping minutes (asleep distal body temperature), and the difference between those averages (asleepawake distal body temperature difference)