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[DOI] [PMC free article] [PubMed] [Google Scholar] 101

Solutions prepared in organic vehicles (DMSO, PEG, oils) are best regarded as short-lived and non-sterile

Src family molecules such as Shc and Lyn, interact with the cytoplasmic domain of the GHR and activate phospholipase C (PLC) which then proceeds to hydrolyse phospholipids to form inositol-1,4,5 triphosphate (IP3) and diacylglycerol (DAG) (47)

Get the ratio wrong and everything downstream falls apart
