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This topic is also discussed, with emphasis on development of mGlu 2 positive allosteric modulators (PAMs)

B12 supports mitochondrial function and cellular energy production through its role in fatty acid oxidation and the citric acid cycle
Pale or jaundiced skin Due to the problems that low levels of B12 cause to the bodys red blood cell production, a common symptom of B12 deficiency is looking pale

the figure shows a strong correlation between percent inhibition of FIGF dimerization (
