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Compared with the control samples, colitis specimens exhibit significantly higher malondialdehyde (MDA) (58) and iron (particularly, ferrous iron) levels (63), and increased cellular iron levels during ferroptosis induce transcriptional upregulation of ferritin (34), which may contribute to the exacerbation of colitis

As a result, the imbalance in MET can intensify glycolysis, leading to substantial lactate generation, which, in turn, weakens CTL activity and promotes immune evasion by tumors