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If the increased demand for choline moieties for myelin synthesis is not accompanied by a proportionate increase in uptake of choline moieties across the BBB, brain tCho signal could be reduced
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These changes could be significant contributors to the decreased auditory sensitivity often associated with aging
Moreover, the transcription factor c-Jun, encoded by the proto-oncogene JUN , upregulates GLS through coordinated transcriptional and post-translational mechanisms
