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Description
While same mitochondrial problems are present in the UMNs of ALS patients with TDP-43 pathology and UMNs of TDP-43 mouse models, and since pathologies are shared at a cellular level, regardless of species, we first analyzed the metabolite profile of both healthy and diseased motor cortex to investigate whether metabolomic changes occur with respect to TDP-43 pathology
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Key metabolomics techniques include mass spectrometry (MS), nuclear magnetic resonance (NMR), liquid chromatography (LC), and gas chromatography (GC)

Also, upregulation of oncogenic pathways has been described in clinically evident precancerous lesions of 12 different types of malignancies [285]
