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Food and Drug Administration (FDA) includes pharmacogenetic information in drug labelingfor instance, issuing warnings about CYP2C19 poor metabolizers and the risk of QT-interval prolongation with citaloprambut does not mandate pre-emptive testing, maintaining a position of enforcement discretion (Drozda et al., 2018)

10.1016/S0014-5793(99)01044-3 43 TorresM

-Glutamylcysteine ligase expression is subject to regulation by Nrf2, a transcription factor that regulates a wide array of antioxidant responsive element (ARE)-driven genes in various cell types, and thus plays a central role in cellular antioxidant defenses (Jaiswal, 2004

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