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The tirzepatide compound dosage chart lays out this progression clearly

When absorption issues are a factor, recovery from a deficiency may take longer, unless B12 is supplied directly through injections

[10] [4] Patients should contact their GP if they experience persistent or severe side effects, signs of allergic reaction (facial swelling, difficulty breathing, severe rash), or if symptoms of B12 deficiency (such as neurological symptoms, severe fatigue, or glossitis) do not improve after several weeks of supplementation

Yes, hydroxocobalamin is often better tolerated by overmethylators