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There has also been a focus on combining this technique with other methods for enhanced epigenomics profiling: nanopore Cas9-targeted sequencing was used for assessing the methylation of O [6]-methylguanine-DNA methyltransferase (MGMT) while simultaneously detecting the isocitrate dehydrogenase (IDH) mutation status in glioma patients, and another method has been developed for concomitantly detecting CpG methylation and chromatin accessibility [6, 103]

Importantly, these peripheral immune cells share functional characteristics with microglia, including the expression of toll-like receptors (TLRs), which enables their activation by aggregated proteins or pathogen-related molecular patterns

A patient education tool will also be created in the form of a brochure format to teach patients about nutritional recommendations that may alleviate their problems associated with liver cirrhosis (Fig