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Methods Search strategy and selection criteria The systematic review protocol was registered in the International Prospective Register of Systematic Reviews (PROSPERO) under registration number CRD420251088025

Injection site e.g., left deltoid, right gluteal

Metal ion coordination and gene regulation Copper-peptide complexes: GHK-Cu contains copper(II) ion coordinated by glycine amino group, histidine imidazole, and lysine forming square planar complex

The rearrangement gives good isolated yields and excellent diastereoselectivity due to (Z)-N,O-ketene acetal formation and the pseudochair-like conformations of reaction intermediates